Will Smith does it again. A virus has wiped out humankind, and as far as Smith's character knows, he’s the last man on earth in 2012. When Neville isn’t hunting for food or gathering supplies, he’s doing research to find a cure for the deadly virus to which he is immune. But the research and exploring can only be done during the day, because night brings out a horror that keeps Neville and his dog Sam hiding behind barricaded doors.